Table 3 |
||
|
Summary of data about toxicology of thujone |
||
|
Toxicity data |
Reference |
|
|
|
||
|
oral LD50 in rats |
192 mg/kg bw |
[66] |
|
oral LD50 in rats |
500 mg/kg bw |
[107] |
|
iv LD50 in rabbits |
0.031 mg/kg bw |
[107] |
|
NOEL for convulsions in rats |
12.5 mg/kg bw (males) |
[108] |
|
NOEL for convulsions in rats |
5 mg/kg bw (females), 10 mg/kg bw (males) |
[66] |
|
NOEL for convulsions in rats |
5 mg/kg bw |
[66] |
|
TDI (based on NOEL with safety factor of 500) |
10 μg/kg bw/d |
[66] |
|
Metabolism |
2-,4-, and 7-hydroxylation |
[75,76] |
|
Mechanism of toxicity |
GABA Type A modulation (α-thujone neurotoxicity, convulsant effects) |
[72,74,76] |
|
Mechanism of toxicity |
Porphyrogenicity (determined in cultures of chick embryo liver cells) |
[46] |
|
Behavioral effects |
5-HT3 receptor modulation, but no conclusive evidence for psychotropic actions of thujone |
[77] |
|
|
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|
Padosch et al. Substance Abuse Treatment, Prevention, and Policy 2006 1:14 doi:10.1186/1747-597X-1-14 |
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