Table 4 |
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|
Results |
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|
Buprenorphine (total = 42) |
Dihydrocodeine (total = 48) |
Relative Risk (95% CI) |
Unpaired t-test |
P value |
|
|
|
|||||
|
By end of detox |
|||||
|
Final urine sample |
32/42 |
31/48 |
1.18 (0.90, 1.54) |
N/A |
0.43 |
|
Per protocol negative urine |
24/32 |
17/31 |
1.37 (0.94, 1.99) |
N/A |
0.10 |
|
ITT negative urine |
24/42 |
17/48 |
1.61 (1.02, 2.56) |
N/A |
0.04 |
|
Leaving early |
10/42 |
15/48 |
0.76 (0.38, 1.51) |
N/A |
0.43 |
|
Overdose |
0 |
0 |
N/A |
||
|
Inappropriate use of allocated drug |
3/29 |
1/25 |
2.59 (0.29,23.32) |
N/A |
0.39 |
|
A&E attendance |
0 |
0 |
N/A |
||
|
Hospital admittance |
0 |
0 |
N/A |
||
|
Prison doctor visits (mean) |
1.0 (0.5) n = 28 |
1.0 (0.6) n = 23 |
N/A |
t(49) = 0.00 |
1.00 |
|
|
|||||
|
At 1 months post detoxification |
|||||
|
|
|||||
|
Dead |
0/33 |
0/33 |
N/A |
||
|
Abstinent (ITT) |
16/42 |
17/48 |
1.08 (0.63, 1.85) |
N/A |
0.79 |
|
How known? |
|||||
|
Urine test |
4/10 |
2/5 |
1.00 (0.27, 3.72) |
N/A |
|
|
Self report |
12/21 |
15/25 |
0.95 (0.58, 1.55) |
N/A |
1.00 |
|
A&E attendance |
0/33 |
0/33 |
N/A |
0.84 |
|
|
Hospital attendance |
0/33 |
0/33 |
N/A |
||
|
Prison doctor visits (mean) |
0.4 (0.9) n = 25 |
0.6 (1.0) n = 28 |
N/A |
t(51) = 0.76 |
0.45 |
|
Drug worker visits (mean) |
0.2 (0.4) n = 3 |
2 n = 1 |
N/A |
||
|
|
|||||
|
At 3 months post detoxification |
|||||
|
|
|||||
|
Dead |
0/27 |
0/23 |
N/A |
||
|
Abstinent (ITT) |
13/42 |
12/48 |
1.24 (0.64, 2.41 |
N/A |
0.53 |
|
How known? |
|||||
|
Urine test |
2/8 |
1/4 |
1.00 (0.13, 8.00) |
N/A |
1.00 |
|
Self report |
11/18 |
11/18 |
1.00 (0.59, 1.68) |
N/A |
1.00 |
|
A&E attendance |
1/27 |
1/23 |
0.85 (0.06,12.87) |
N/A |
0.91 |
|
Hospital attendance |
2/27 |
1/23 |
1.70 (0.16,17.60) |
N/A |
0.65 |
|
Prison doctor visits (mean) |
0.8 (1.7) n = 17 |
1.5 (1.9) n = 17 |
N/A |
t(32) = 0.76 |
0.27 |
|
Drug worker visits (mean) |
0 |
No data |
N/A |
||
|
|
|||||
|
At 6 months post detoxification |
|||||
|
|
|||||
|
Dead |
0/14 |
0/12 |
|||
|
Abstinent |
5/42 |
5/48 |
1.14 (0.36, 3.68) |
N/A |
0.82 |
|
How known? |
|||||
|
Urine test |
1/3 |
1/4 |
1.33(0.13,13.74) |
N/A |
0.81 |
|
Self report |
4/11 |
4/8 |
0.73 (0.26, 2.07) |
N/A |
0.55 |
|
A&E attendance |
2/14 |
1/12 |
1.71(0.18,16.65) |
N/A |
0.64 |
|
Hospital attendance |
3/14 |
2/12 |
1.29 (0.26, 6.46) |
N/A |
0.76 |
|
Prison doctor visits (mean) |
2.0 (2.2) n = 4 |
2.2 (1.5) n = 4 |
N/A |
||
|
Drug worker visits (mean) |
No data |
N/A |
|||
|
|
|||||
|
*ITT assumption = everybody not returning for final urine test had positive urine * Statistical tests were z (approximation) tests |
|||||
|
Sheard et al. Substance Abuse Treatment, Prevention, and Policy 2009 4:1 doi:10.1186/1747-597X-4-1 |
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