Skip to main content

Auricular acupuncture for chemically dependent pregnant women: a randomized controlled trial of the NADA protocol

Abstract

Background

The prevalence of maternal drug use during pregnancy in North America has been estimated to be as high as 6-10%. The consequences for the newborn include increased risk for perinatal mortality and ongoing physical, neurobehavioral, and psychosocial problems. Methadone is frequently used to wean women off street drugs but is implicated as a cause of adverse fetal/neonatal outcomes itself. The purpose of our study was to test the ability of maternal acupuncture treatment among mothers who use illicit drugs to reduce the frequency and severity of withdrawal symptoms among their newborns.

Methods

We randomly assigned chemically dependent pregnant women at BC Women’s Hospital in Vancouver, British Columbia to daily acupuncture treatments versus usual care. By necessity, neither our participants nor acupuncturists were blinded as to treatment allocation. Our primary outcome was days of neonatal morphine treatment for symptoms of neonatal withdrawal. Secondary neonatal outcomes included admission to a neonatal ICU and transfer to foster care.

Results

We randomized 50 women to acupuncture and 39 to standard care. When analyzed by randomized groups, we did not find benefit of acupuncture; the average length of treatment with morphine for newborns in the acupuncture group was 2.7 (6.3) compared to 2.8 (7.0) in the control group. Among newborns of women who were compliant with the acupuncture regime, we observed a reduction of 2.1 and 1.5 days in length of treatment for neonatal abstinence syndrome compared to the non-compliant and control groups, respectively. These differences were not statistically significant.

Conclusions

Acupuncture may be a safe and feasible treatment to assist mothers to reduce their dosage of methadone. Our results should encourage ongoing studies to test the ability of acupuncture to mitigate the severity of neonatal abstinence syndrome among their newborns.

Clinical Trial Registration

http://www.clinicaltrials.gov registry: W05-0041

Background

The prevalence of maternal drug use during pregnancy in Canada [1] and the US [2] has been estimated to be as high as 6-10%. The consequences for the newborn are severe, and include increased risk for perinatal mortality and morbidity, as well as ongoing physical, neurobehavioral, and psychosocial problems [37]. Between 60-90% of infants exposed to illicit drugs in utero will exhibit clinical symptoms of withdrawal, particularly if opiates are among the drugs used [810].

Methadone treatment is currently the recommended approach to opiate addiction during pregnancy [11]. The purpose of this treatment is to alleviate the symptoms of drug withdrawal in order to prevent use of street drugs. It is widely believed that intrauterine death or fetal compromise is due to the “bingeing” or drastic fluctuations in serum levels of opiates or cocaine associated with “street” use [12]. Methadone substantially minimizes the peak and trough in maternal serum opioid levels that typically occur with repeat use of short-acting opioids such as heroin, thereby reducing the harm that the fetus encounters as a result of repeated intoxication and withdrawal [13]. Methadone use during pregnancy has been associated with improved prenatal care, [14] longer gestation, [15] higher birthweight, [16] and increased rates of infants discharged home in the care of their mothers [17]. In hospital, the dosage of methadone is tailored to the mother’s tolerance of symptoms and is titrated over a 24-hour period to avoid fluctuations in levels of methadone in the fetal circulation. Unfortunately, if symptoms are not well controlled with methadone use, or perhaps even if they are, women frequently continue to use other drugs [18]. Methadone itself is highly addictive and is implicated as a cause of adverse fetal/neonatal sequelae [19, 20]. Methadone-exposed babies have demonstrated reduced birth weight and head circumference, prematurity, [21] and rates of neonatal withdrawal syndrome ranging from 46% [22] to 97% [12, 23]. A dose–response relationship between methadone and neonatal abstinence syndrome (NAS) has been reported in a large series of 618 women [24] but a meta-analysis by the same author [23] and others [25] did not confirm these findings. A recent prospective study by this group concluded that neonates exposed to methadone doses ≥ 80 mg required higher cumulative doses of morphine treatment for NAS but attributed this to concomitant use of other drugs [26]. Increased rates of congenital anomalies have been reported in non-randomized studies, [12, 24, 27] but these have not yet been evaluated in randomized designs [28] capable of controlling for concomitant consumption of other substances.

While the physiological mechanisms underlying acupuncture have yet to be unambiguously identified, the balance of evidence favours quantitative differences in electrodermal properties between acupuncture points and surrounding skin [29, 30]. There is also emerging evidence of correlations between connective tissue anatomy, microcirculatory blood flow, and acupuncture needling points [31]. Acupuncture in the context of addiction is still relatively new [3235]. Acupuncture points are cutaneous areas containing relatively large concentrations of free nerve endings [36]. The acupuncture stimulus is transmitted to the spinal cord by afferent peripheral nerves [34]. Acupuncture is believed to stimulate the release of endorphins [37] from the pituitary gland and the hypothalamus. Endorphins are neurotransmitters involved in pain inhibition. They are 10–100 times more potent than morphine and may circulate for several hours. Levels of endorphins have been shown to increase after acupuncture in animal models [38, 39]. Alcohol and opioids may preferentially bind to endorphin receptors and thereby displace endogenous endorphins [40, 41]. Over time the production and action of the natural endorphins is inhibited. Craving during withdrawal from illicit opioids may result from a deficiency in endogenous opioids as well as from other neurochemical defects associated with drug abuse [40].

The role of acupuncture in the treatment of addiction was discovered serendipitously [42] and subsequently refined at the Lincoln Recovery Center in Bronx, New York where the National Acupuncture Detoxification Association (NADA) protocol was developed [43]. A randomized controlled trial of NADA auricular acupuncture utilizing analysis of urine screens showed that acupuncture significantly reduced cocaine use compared with each of two control conditions [32].

There have been no studies to date specifically addressing the use of acupuncture for treatment of substance abuse in pregnancy. The purpose of this study is to determine the efficacy of daily maternal acupuncture treatments in reducing the frequency and severity of (NAS) among infants born to substance-using women.

Methods

We conducted a randomized controlled trial of methadone maintenance (standard treatment) to chemically dependent hospitalized pregnant women vs. methadone combined with the offer of daily acupuncture treatments. Our primary outcome was the number of days that neonates were treated with morphine for neonatal withdrawal syndrome. We received ethical approval from the University of British Columbia Clinical Ethics Research Board and the BC Women’s Hospital Research Review Committee.

Setting

We conducted our study at BC Women’s Hospital in Vancouver, British Columbia between July 15, 2005-April 30, 2008. Chemically dependent women living in Vancouver and surrounding suburbs are referred to the BC Women’s Chemical Dependency Unit by their primary caregiver as soon as they present for prenatal care, usually in the second trimester. They are admitted to the chemical dependency unit on a voluntary basis. They are offered a methadone maintenance program or support to withdraw from methadone and other illicit drugs. After an initial stay of approximately two months, they are discharged then readmitted approximately two weeks prior to their due date. After the birth, mothers and their newborns are discharged together when the baby is stable, gaining weight, and does not require treatment for symptoms of NAS. The unit is built on an empowerment model in which women have access to a variety of “healing” activities such as yoga, gardening, therapeutic touch, peer support groups, arts and crafts, group walks and massage therapy. Residents participate in their own discharge planning meetings. Sessions with alcohol and drug support counsellors are available on the unit. Urine testing is not done. Babies room in with their mothers unless neonatal intensive care is required. All women admitted to the Chemical Dependency Unit at BC Women’s Hospital were offered participation in the current study.

Sample

Women admitted to the chemical dependency unit at BC Women’s Hospital, Vancouver, B.C. were considered to be eligible for inclusion. Exclusion criteria consisted of inability to read or write English, having a pacemaker or other electrical implant, having a bleeding disorder, or a condition putting someone at particular risk for infection, including for example, damaged heart valves, diabetes requiring insulin, immunosuppressive drug therapy or open wounds.

Outcome measures

Number of days of treatment of the newborn with morphine was chosen as the primary outcome because it is a clinical measure of the time required for the newborn to complete withdrawal from opiates. In this unit, morphine is prescribed for the neonate by pediatricians if there is a constellation of symptoms unresponsive to environmental control including: 1) convulsions, 2) inconsolability or crying continuously for 3 hours, 3) persistent tremors or jitteriness when undisturbed, 4) continuous central nervous system irritability including hyperactive Moro reflex, tremors, jitteriness, increased muscle tone and unprovoked muscle jerks, 5) persistent vomiting or projectile vomiting over a 12 hour period, or 6) explosive diarrhea for 2–3 consecutive episodes [44]. Additional clinical signs such as tachycardia, tachypnea, watery stools, fever, or weight loss > 10% may justify use of morphine after consideration of differential diagnoses. Morphine 1 mg/ml is started at a rate of 0.03 mg/kg/dose every 3 hours. The dose is reviewed daily and titrated based on daily weights and ongoing symptoms.

Secondary neonatal outcomes include gestational age at birth, Apgar scores, days to regain birth weight, rates of admission to a neonatal intensive care nursery, withdrawal symptoms and rates of transfer of the infant to foster care. Infants experiencing NAS have been shown to require significantly longer time to regain their birthweight [45]. Neonatal outcomes were ascertained from the hospital chart by a research assistant blinded to study allocation. Withdrawal symptoms are routinely documented by nurses using a modified version of the Finnegan Scale [46]. Nurses were not formally blinded to study allocation. The Finnegan scale has been widely used in studies of NAS [47, 48] and has been shown to be a valid standard against which pharmacologic treatment can be titrated [49, 50]. The original 22-item-scale instrument consists of variables such as sleep duration after feeding, mottling, and nasal stuffiness. We report on a subset of more objective items that are documented daily on the unit including high pitched cry, inconsolable crying, tremors, muscle tone, sucking and swallowing, vomiting and diarrhea.

Study protocol

Women were recruited on the unit by a trial coordinator. After obtaining written informed consent a sequentially numbered opaque envelope was opened to reveal the study allocation by the study research assistant. Random allocation to study arm was undertaken using statistical software, SPSS version 18.

We used the National Acupuncture Detoxification Association (NADA) five-point auricular acupuncture protocol for treating symptoms of drug withdrawal [43]. The protocol consists of inserting five stainless steel acupuncture needles in both ears at points known as Sympathetic, Shen men, Liver, Kidney, and Lung. This point combination is believed to be specific for substance abuse. The acupuncturist swabbed the ears with alcohol and inserted sterile, disposable needles. Following the 45 minute treatment, participants removed the needles and placed them in protective sharps boxes in order to minimize risk of needlestick injury to the acupuncturist. All needles were counted to ensure that all had been retrieved and disposed of. A sham acupuncture procedure was not used. Chinese traditional medicine does not include the concept of a placebo [51]. Those who argue that auricular acupuncture stimulates the vagus nerve, which innervates the ear concha, state that needles placed anywhere in the concha should produce the same effects [52]. Studies utilizing sham procedures have failed to show a difference between the control and active experimental conditions [51, 53].

Women participating in the treatment group of our study were given access to a quiet room furnished with comfortable reclining chairs. The acupuncturist spent approximately 30 minutes with them each day.

Physicians prescribing morphine to newborns were blinded as to treatment arm. Assignment to trial arm was not written in the chart. Women received acupuncture treatment at mid-day when pediatricians were not usually on the unit and in a room with the door shut. Mothers were asked not to tell physicians if they were receiving acupuncture.

Sample size

We planned to have 80% power to detect a 30% reduction of days of neonatal morphine treatment, from 11.75 (5.2) to 8.25 days (5.2) with 37 subjects per treatment arm. The baseline rate of 11.75 days was derived from a pilot study of this population at BC Women’s by one of the authors (RA) [54].

Data analysis

Data analysis was by intention to treat. Outcomes of participants were analyzed within the trial arm that they were randomly assigned to. Socio-demographic characteristics assessed at baseline included age, marital status, ethnicity, income, parity, housing (stable vs. transient), smoking status and education. Pregnancy-related characteristics assessed included pre-pregnant weight and weight gain, month of entry to prenatal care, and self-reported substance use. Tests of normality (Kolmogorov-Smirnov) were applied to continuous variables. Normally distributed continuous variables were compared between groups using the t-test. Non- normally distributed variables were compared using the Mann–Whitney U test for two groups and the Kruskal-Wallis test for three groups. Discrete variables were compared between groups using the chi-square statistic when expected cell counts were greater than five; otherwise the Fisher’s exact test was reported. Statistical analysis was undertaken using SPSS, version 18.

Results

Among 190 eligible women approached to participate in the study, 89 agreed to participate (Figure 1). Three women in the acupuncture group delivered prematurely or precipitously prior to receiving a treatment. Outcomes could not be ascertained for 2 women in the acupuncture group and one in the control group because they delivered outside of BC Women’s Hospital at an unknown location. Forty-seven women received acupuncture treatments and 39 received standard ward care. Study groups were comparable with respect to demographic status including age, presence of support persons, education, and sources of income (Table 1). Groups did not differ with respect to substance use in previous pregnancies, retention of custody of previously born children, and use of alcohol, tobacco, crack, cocaine, crystal meth, heroin or other opioids, benzodiazepines, or ecstasy (Table 2). Women in each study arm did not differ with respect to pre-pregnant weight, height, weight gain during the pregnancy, or gestational age at entry to prenatal care (Table 3). The average length of stay on the unit was similar in the acupuncture and control groups. Dosage of methadone on admission to hospital was higher on average by 10 mg in the acupuncture group. Mode of delivery and rates of breastfeeding did not differ between groups. Analyzed by intention to treat, there were no differences in days of morphine treatment between treatment groups. Similarly, groups did not differ with respect to newborn Apgar scores at one or five minutes, admission to neonatal intensive care unit (ICU), days to regain birthweight, apprehension of the baby to foster care, or symptoms of neonatal abstinence (Table 4).

Figure 1
figure 1

Flow chart of Participant Eligibility, Recruitment, and Compliance.

Table 1 Sociodemographic profile of study participants
Table 2 Substance use profile of study participants on admission to hospital
Table 3 Pregnancy-related characteristics of participants
Table 4 Maternal and newborn outcomes

Compliance with the acupuncture regime varied greatly among participants, as did time spent on the hospital unit. When we compared compliant participants, defined as those who received the highest quartile of acupuncture treatments, (nine or more treatments), (n=13) with those who did not (n=27) in the acupuncture group, and controls (n=32) in a post hoc analysis, those in the compliant group were taking higher doses of methadone at delivery (Table 5). The reduction in use of methadone from first admission to hospital to delivery was larger in the acupuncture-compliant group compared to the acupuncture non-compliant group and the control group. These findings would suggest that women who require higher doses of methadone were more compliant with treatment, perhaps because they believed it to be helpful. On this basis we undertook an additional “as treated” analysis, comparing women who had nine or more acupuncture treatments with those who were non-compliant (less than nine) and control subjects. We further restricted this analysis to women who had some ingestion of opioid, as there were fourteen women in the study who ingested only crack or cocaine and two who were exposed only to crystal meth.

Table 5 Maternal and newborn outcomes in an “as treated” analysis among mothers exposed to opiates

In this analysis newborns of women in the acupuncture-compliant group experienced a reduction of 2.1 and 1.5 days in length of treatment for neonatal abstinence syndrome compared to the non-compliant and control groups, respectively. These differences were not statistically significant (Table 5). With the exception of inconsolable crying, their newborns exhibited symptoms of NAS for fewer days. These differences were not statistically significantly different.

Discussion

We report that the offer of acupuncture to hospitalized chemically dependent women in a randomized design is not associated with improved perinatal outcomes. In the current study, only 28% of women in our acupuncture arm were protocol-compliant. Women in our study who were compliant were found to be receiving higher doses of methadone on admission to hospital and reduced their dosage of methadone to a greater degree than either the non-compliant women in the acupuncture-group or the control group. This would suggest that women who would be expected to suffer most from withdrawal symptoms remained compliant because they believed that the acupuncture was helping them. Indeed they were able to tolerate larger reductions in their methadone dose prior to delivery and their babies required almost two fewer days of morphine treatment. As well, the babies in this small group were documented by nurses using a standardized symptom log to have had symptoms of neonatal withdrawal for shorter periods of time.

Factors promoting compliance have been understudied in women who are addicted to illicit drugs. Women in our study who were non-compliant most often told the acupuncturist that they were “too busy” to receive a treatment, although there was no apparent reason to be busy on the hospital ward. In a previous study of acupuncture in a non-pregnant population, the authors demonstrated a reduction in use of illicit drugs among participants who came consistently for acupuncture, but only 15 percent of attendees to the clinic remained compliant [34].

Non-compliance further limits our study by reducing the number of exposed subjects in our study arm and thus our power to detect differences. The non-statistically significant reduction in duration of morphine treatment among newborns whose mothers were compliant with acupuncture should be confirmed in future studies. This clinically relevant difference, if confirmed, could result in earlier discharge for mother-infant dyads. Investigators working with similar populations would be well advised to consider a “run-in” period to measure compliance prior to randomization. As well, our power to detect differences in study outcomes was further limited by the fact that our sample size calculations were based on longer periods of morphine treatment than those observed in our study.

We conducted our study in a hospital unit designed specifically for chemically dependent women. As such, women readily disclosed the nature of their drug dependency without fear of retribution or random urine testing for themselves or their newborns. There is no coercion to participate in the study as the unit is funded through our provincial health care program and is therefore free of charge. However, the variety of services available to women on the ward, such as Narcotics Anonymous meetings, yoga, and other activities, may have reduced the potency of the acupuncture intervention.

Controversy regarding the relationship between methadone dose and the incidence and severity of (NAS) [23] raises new challenges for evaluating the effectiveness of measures aimed at reducing maternal substance use. It also begs the question of whether or not there are more subtle measures of opioid sequelae in the newborn that could be measured or whether long term sequelae may exist in the absence of NAS. Some authors have noted that opioid exposed infants may exhibit subacute NAS symptoms for weeks to months after birth [55]. If the severity of NAS remains problematic as a measure of maternal drug exposure, then ongoing studies will benefit from more accurate measures of maternal substance use that would not in turn deter women from participation in research studies. Ideally such studies would be conducted in an outpatient setting in which assessment of maternal exposure could include self report, voluntary testing, and observation by outreach/case workers and counsellors.

Conclusions

Our findings, while not conclusive, should encourage the continuing study of acupuncture as a safe and “low tech” intervention which can be administered during pregnancy. Our findings of potentially shorter duration of NAS among newborns of mothers who received acupuncture, while limited to a small group, deserve further study. Potential investigators should be aware that while chemically dependent women are willing to participate in a randomized controlled trial of acupuncture, attrition rates are high and measures should be taken to enrol women who have demonstrated the ability to remain compliant with acupuncture protocols.

Authors’ information

PJ is a registered nurse and perinatal epidemiologist whose research focus is aimed at birth outcomes among women from marginalized populations. LD is a practicing doctor of traditional Chinese medicine. AK is a perinatal epidemiologist whose research focus is addiction in pregnancy. PT is a pediatrician. RA is a family practice physician and Medical Director, Perinatal Addictions, BC Women’s Hospital in Vancouver, British Columbia, Canada.

Abbreviations

NAS:

Neonatal Abstinence Syndrome.

References

  1. Albersheime S: Infants of drug-dependent mothers. Can J Pediatr. 1992, 4: 70-72.

    Google Scholar 

  2. Arria A, Derauf C, Lagasse L, Grant P, Shad E, Smith L: Methamphetamine and other substance use during pregnancy: preliminary estimates from the Infant Development, Environment and Lifestyle (IDEAL) study. Matern Child Health J. 2006, 10 (3): 293-302. 10.1007/s10995-005-0052-0.

    Article  PubMed  Google Scholar 

  3. Neonatal Abstinence. Edited by: Finnegan L. 1990, Hamilton (Ont): Decker

    Google Scholar 

  4. Maternal and neonatal effects of alcohol and drugs. Edited by: Finnegan L, Kandall S. 1993, Baltimore: Williams & Wilkins

  5. Alkalay A, Pomerance J, Hamlett H: Substance abuse and the newborn. Review, management and practice guidelines: part II. Neonatal Intensive Care. 1997, 10 (7): 44-46.

    Google Scholar 

  6. Dattell B: Substance abuse in pregnancy. Semin Perinatol. 1990, 14 (2): 179-187.

    Google Scholar 

  7. D’Apolito K: Symptoms of withdrawal in drug-exposed infants. Mother Baby J. 1996, 1 (2): 7-14.

    Google Scholar 

  8. Chasnoff I: Newborn infants with drug withdrawal symptoms. Pediatr Rev. 1988, 9: 273-277. 10.1542/pir.9-9-273.

    Article  CAS  PubMed  Google Scholar 

  9. Fergusson D, Horwood L, Sjannon F, Lawton J: The Christchurch child development study: a review of epidemiological findings. Paediatr Perinat Epidemiol. 1989, 3: 278-301. 10.1111/j.1365-3016.1989.tb00379.x.

    Article  Google Scholar 

  10. Madden J, Chapel J, Zuspan F, Gumpel J, Mefia A, Davis R: Observation and treatment of neonatal narcotic withdrawal. Am J Obstet Gynecol. 1977, 127 (2): 199-201.

    CAS  PubMed  Google Scholar 

  11. Wong S, Ordean A, Kahan M: SOGC clinical practice guidelines: substance use in pregnancy, No. 156. Int J Obstet Gynecol. 2011, 114: 190-202.

    Article  Google Scholar 

  12. Brown H, Britton K, Mahaffay D, Brizendine E, Hiett A, Turnquest M: Methadone maintenance in pregnancy; a reappraisal. Am J Obstet Gynecol. 1998, 179 (2): 459-463. 10.1016/S0002-9378(98)70379-5.

    Article  CAS  PubMed  Google Scholar 

  13. Jones H, Martin P, Heil S, Kaltenbach K, Selby P, Coyle M: Treatment of opioid-dependent pregnant women: clinical and research issues. J Subst Abuse Treat. 2008, 35: 245-259. 10.1016/j.jsat.2007.10.007.

    Article  PubMed Central  PubMed  Google Scholar 

  14. Jones H, O’Grady K, Malfi D, Tuten M: Methadone maintenance vs. methadone taper during pregnancy: maternal and neonatal outcomes. Am J Addict. 2008, 17: 372-386. 10.1080/10550490802266276.

    Article  PubMed  Google Scholar 

  15. Hagopian G, Wolfe H, Sokol R, Ager J, Wardell J, Cepeda E: Neonatal outcome following methadone exposure in utero. J Matern Fetal Med. 1996, 1996 (5): 348-354.

    Google Scholar 

  16. Hulse G, Milne E, English D, Holman C: The relationship between maternal use of heroin and methadone and infant birth weight. Addiction. 1997, 92: 1571-1579. 10.1111/j.1360-0443.1997.tb02877.x.

    Article  CAS  PubMed  Google Scholar 

  17. Hunt R, Tzioumi D, Collins E, Jeffery H: Adverse neurodevelopmental outcome of infants exposed to opiate in-utero. Early Hum Dev. 2008, 84: 29-35. 10.1016/j.earlhumdev.2007.01.013.

    Article  CAS  PubMed  Google Scholar 

  18. Hulse G, O’Neill G: Methadone and the pregnant user: a matter for careful clinical consideration. Aust N Z J Obstet Gynaecol. 2001, 41 (3): 329-332. 10.1111/j.1479-828X.2001.tb01239.x.

    Article  CAS  PubMed  Google Scholar 

  19. Hunt R, Tzioumi D, Collins E, Jeffrey H: Adverse neurodevelopmental outcome of infants exposed to opiate in utero. Early Hum Dev. 2008, 84 (1): 29-35. 10.1016/j.earlhumdev.2007.01.013.

    Article  CAS  PubMed  Google Scholar 

  20. McGlone L, Mactier H, Hamilton R, Bradnam M, Boulton R, Borland W: Visual evoked potentials in infants exposed to methadone in utero. Arch Dis Child. 2008, 93 (3): 784-786.

    Article  CAS  PubMed  Google Scholar 

  21. Lejeune C, Aubisson S, Simmat-Durand L, Cneude F, Piquet M, Gourarier L, Le Group d’Etudes Grossesse et Addictions: Withdrawal syndromes of newborns of pregnant drug abusers maintained under methadone or high-dose buprenorphine: 246 cases. [French]. Ann Med Intern (Paris). 2001, 152 (Suppl.(7)): 21-27.

    Google Scholar 

  22. Dashe J, Sheffield J, Olscher D, Todd S, Jackson G, Wendel G: Relationship between maternal methadone dosage and neonatal withdrawal. Obstet Gynecol. 2002, 100: 1244-1249. 10.1016/S0029-7844(02)02387-6.

    Article  CAS  PubMed  Google Scholar 

  23. Cleary B, Donnelly J, Strawbridge D, Gallagher P, Fahey T, Clarke T: Methadone dose and neonatal abstinence syndrome -systematic review and meta-analysis. Addiction. 2010, 104: 2071-2084.

    Article  Google Scholar 

  24. Cleary B, Donnelly J, Strawbridge D, Gallagher P, Fahey T, White M: Methadone and perinatal outcmes: a retrospective cohort study. Am J Obstet Gynecol. 2011, 204 (139): e1-e9.

    PubMed  Google Scholar 

  25. Thajam D, Atkinson D, Sibley C, Lavender T: Is neonatal abstinence syndrome related to the amount of opiate used?. JOGNN. 2010, 39: 503-509. 10.1111/j.1552-6909.2010.01174.x.

    Article  PubMed  Google Scholar 

  26. Cleary B, Eogan M, O’Connell M, Fahey T, Gallagher P, Clarke G: Methadone and perinatal outcomes: a prospective cohort study. Addiction. 2012, 107 (8): 1482-1492. 10.1111/j.1360-0443.2012.03844.x.

    Article  PubMed  Google Scholar 

  27. Malpas T, Darlow B, Lennox R, Horwood L: Maternal methadone dosage and neonatal withdrawal. Austr NZ J Obstetr Gynaecol. 1995, 35: 175-177. 10.1111/j.1479-828X.1995.tb01863.x.

    Article  CAS  Google Scholar 

  28. Jones H, Kaltenbach K, Heil S, Stine S, Coyle M, Arria A: Neonatal abstinence syndrome after methadone or buprenorphine exposure. N Engl J Med. 2010, 363: 2320-2331. 10.1056/NEJMoa1005359.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  29. Ahn A, Martinsen O: Electrical characterization of acupuncture points: technical issues and challenges. J Altern Complement Med. 2007, 13: 817-824. 10.1089/acm.2007.7193.

    Article  PubMed Central  PubMed  Google Scholar 

  30. Colbert A, Spaulding K, Ahn A, Cutro J: Clinical untility of electrodermal activity at acupuncture points: a narrative review. Acupunct Med. 2011, 29: 270-275. 10.1136/acupmed-2011-010021.

    Article  PubMed  Google Scholar 

  31. Hsiu H, Hsu W, Hsu C, Huang S: Assessing the effects of acupuncture by comparing needling the hegu acupoint and needling nearby nonacupoints by spectral analysis of microcirculatory laser doppler signals. Evid Based Complement Alternat Med. 2011, 10.1093/ecam/neq073.

    Google Scholar 

  32. Avants S, Margolin A, Holgord T, Kosten T: A randomized controlled trial of auricular acupuncture for cocaine dependence. Arch Intern Med. 2000, 160 (15): 2305-2313. 10.1001/archinte.160.15.2305.

    Article  CAS  PubMed  Google Scholar 

  33. Gurevich M, Duckworth D, Imhof J, Katz J: Is auricular acupuncture beneficial in the inpatient treatment of substance-abusing patients? a pilot study. J Subst Abuse Treat. 1996, 13: 165-171. 10.1016/0740-5472(96)00028-1.

    Article  CAS  PubMed  Google Scholar 

  34. Janssen P, Demorest L, Whynot E: Acupuncture for substance abuse treatment in the Downtown Eastside of Vancouver. J Urban Health. 2005, 12 (2): 285-295.

    Article  Google Scholar 

  35. Lipton D, Brewington V, Smith M: Acupuncture for crack-cocaine detoxification: experimental evaluation of efficiacy. J Subst Abuse Treat. 1994, 11 (3): 205-215. 10.1016/0740-5472(94)90077-9.

    Article  CAS  PubMed  Google Scholar 

  36. Smith F: Neurophysiologic basis of acupuncture. Probl Vet Med. 1992, 4 (1): 34-52.

    PubMed  Google Scholar 

  37. Levine D: Acupuncture in review: a mechanistic perspective. Am J Acupunct. 1980, 8 (1): 5-17.

    Google Scholar 

  38. Wang Y, Wang S: Effects of phentolamine and propanolol on the changes of pain threshold and contents of MEK and LEK in rat brain after EA. J Tradit Chin Med. 1988, 9 (3): 210-214.

    Google Scholar 

  39. Pan X, Zhang B, Wang D: Electro-acupuncture analgesia and analgesic action of NAGA. J Tradit Chin Med. 1984, 4 (4): 273-278.

    CAS  PubMed  Google Scholar 

  40. Culliton P, Kiresuk T: Overview of substance abuse acupuncture treatment research. J Altern Complement Med. 1996, 2 (1): 149-159. 10.1089/acm.1996.2.149.

    Article  CAS  PubMed  Google Scholar 

  41. Barrios De Tomasi E, Juárez-González J: Opioid antagonists and alcohol consumption. Rev Neurol. 2007, 3: 155-162.

    Google Scholar 

  42. Wen H: Role of acupuncture in narcotic withdrawal. Med Pr. 1975, 2: 15-16.

    Google Scholar 

  43. Smith M: Acupuncture and natural healing in drug detoxification. Am J Acupunct. 1979, 7 (2): 97-107.

    Google Scholar 

  44. British Columbia Reproductive Care Program: Perinatal opioid exposure, care of the newborn, substance Use guideline 4B. 1999, Vancouver: British Columbia Reproductive Care Program

    Google Scholar 

  45. Weinberger S, Kandal S, Doberczak T, Thornton J, Bernstein J: Early weight-change patterns in neonatal abstinence. Am J Dis Child. 1986, 140 (8): 829-832.

    CAS  PubMed  Google Scholar 

  46. Finnegan L, Connaughton J, Kron R, Emich J: Neonatal abstinence syndrome: assessment and management. Addict Disord. 1975, 2 (1–2): 141-158.

    CAS  Google Scholar 

  47. Elliott M, Cunliffe P, Demianczuk N, Robertson C: Frequency of newborn behaviours associated with neonatal abstinence syndrome. J Obstet Gynecol Can. 2004, 26 (1): 25-34.

    Google Scholar 

  48. Kandall S: Treatment strategies for drug-exposed neonates. Clin Perinatology. 1999, 26 (2): 231-243.

    CAS  Google Scholar 

  49. Coghlan D, Milner M, Clarke T: Neonatal abstinence syndrome. Ir Med J. 1999, 92: 232-236.

    CAS  PubMed  Google Scholar 

  50. Richardson R, Bolisetty S, Ingall C: The profile of substance-abusing pregnant mothers and their newborns at a regional rural hospital in New South Wales. Austr NZ J Obstet Gynaecol. 2001, 41 (4): 415-419. 10.1111/j.1479-828X.2001.tb01320.x.

    Article  CAS  Google Scholar 

  51. Avants S, Margolin A, Chang P, Kosten T, Birch S: Acupuncture for the treatment of cocaine addiction - investigation of needle puncture control. J Subst Abuse Treat. 1995, 12: 195-205. 10.1016/0740-5472(95)00014-V.

    Article  CAS  PubMed  Google Scholar 

  52. He L: Review article: involvement of endogenous opioid peptides in acupuncture analgesia. Pain. 1987, 31: 99-121. 10.1016/0304-3959(87)90011-X.

    Article  CAS  PubMed  Google Scholar 

  53. Margolin A, Chang P, Avants S, Dosten T: Effects of sham and acupuncture needling: implications for trials of acupuncture for cocaine addiction. Am J Chin Med. 1993, 21: 102-111.

    Article  Google Scholar 

  54. Abrahams R, Kelly A, Payne S, Thiessen P, Mackintosh J, Janssen P: Outcomes of a rooming-in program for women maintained on methadone. Can Fam Physician. 2007, 53 (10): 1722-1730.

    PubMed Central  PubMed  Google Scholar 

  55. Jansson L, Velez M, Harrow C: The opioid exposed newborn: assessment and pharmacologic management. J Opioid Man. 2009, 5: 47-55.

    Google Scholar 

Download references

Acknowledgements

PJ is supported as a Research Scientist Level III Investigatorship from the Child and Family Research Institute, in Vancouver, British Columbia. This study was funded by the Sick Kids Foundation, Toronto, Ontario, Canada.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Patricia A Janssen.

Additional information

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

PJ, LD, AK, PT, and RA contributed to the conception and design of the study. PJ, LD, and AK, contributed to the analysis and interpretation of data. All authors undertook critical revision of the manuscript for intellectual content and approved the final version of the manuscript submitted for publication.

Authors’ original submitted files for images

Below are the links to the authors’ original submitted files for images.

Authors’ original file for figure 1

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and permissions

About this article

Cite this article

Janssen, P.A., Demorest, L.C., Kelly, A. et al. Auricular acupuncture for chemically dependent pregnant women: a randomized controlled trial of the NADA protocol. Subst Abuse Treat Prev Policy 7, 48 (2012). https://doi.org/10.1186/1747-597X-7-48

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/1747-597X-7-48

Keywords